pentobarbital will decrease the level or result of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital will lessen the level or impact of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Solid CYP3A4 inducers might lower midostaurin concentrations r